KMID : 0606920230310040417
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Biomolecules & Therapeutics 2023 Volume.31 No. 4 p.417 ~ p.424
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6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson¡¯s Disease Mouse Model
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Huh Eu-Gene
Choi Jin-Gyu Choi Yu-Jin Ju In-Gyoung Noh Dong-Jin Shin Dong-Yun Chon Jin-Young Park Hi-Joon Oh Myung-Sook
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Abstract
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Parkinson¡¯s disease (PD) which has various pathological mechanisms, recently, it is attracting attention to the mechanism via microbiome-gut-brain axis. 6-Shogaol, a representative compound of ginger, have been known for improving PD phenotypes by reducing neuroinflammatory responses. In the present study, we investigated whether 6-shogaol and ginger attenuate degeneration induced by Proteus mirabilis (P. mirabilis) on the intestine and brain, simultaneously. C57BL/6J mice received P. mirabilis for 5 days. Ginger (300 mg/kg) and 6-shogaol (10 mg/kg) were treated by gavage feeding for 22 days including the period of P. mirabilis treatment. Results showed that 6-shogaol and ginger improved motor dysfunction and dopaminergic neuronal death induced by P. mirabilis treatment. In addition, they suppressed P. mirabilis-induced intestinal barrier disruption, pro-inflammatory signals such as toll-like receptor and TNF-¥á, and intestinal ¥á-synuclein aggregation. Moreover, ginger and 6-shogaol significantly inhibited neuroinflammation and ¥á-synuclein in the brain. Taken together, 6-shogaol and ginger have the potential to ameliorate PD-like motor behavior and degeneration of dopaminergic neurons induced by P. mirabilis in mice. Here, these findings are meaningful in that they provide the first experimental evidence that 6-shogaol might attenuate PD via regulating gut-brain axis.
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KEYWORD
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Parkinson¡¯s disease, Microbiota-Gut-Brain axis, 6-shogaol, ginger, Proteus mirabilis
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